1. 简介

  王华，博士、教授，博士生导师，安徽省学术和技术带头人后备人选，美国堪萨斯大学医学研究中心访问学者，现任院长助理和卫生毒理学系常务副主任。研究方向为发育与生殖毒理学。任中国毒理学会青年委员会常务委员和生化与分子毒理学专业委员会委员、中国环境诱变剂学会致癌专业委员会委员、安徽省环境诱变剂学会常务理事兼副秘书长以及安徽省预防医学会卫生毒理学会委员兼秘书。近年来，主持国家自然科学基金2项以及省优青和省转化医学各1项，参加国家自然科学基金项目5项和省部级课题7项，以第一作者或通讯作者发表SCI论文35篇，获安徽青年科技奖，省部级一等奖1项、二等奖2项和三等奖4项，省自然科学优秀学术论文一等奖2项，并先后获中国毒理学会首届优秀青年科技人才奖、中国药理学会Servier青年药理学家奖和安徽医科大学首届十佳科技新星。教学方面，主持校级青年教师教学研究项目1项，指导本科生成功申报大学生国家级创新训练项目1项；曾获校级优秀教师、校级教坛新秀和学校优秀教案评比一等奖；主编人民卫生出版社《实验技术中的惑与获》，参编教材与著作6部。环境与职业医学编委，Environment International、Toxicological Sciences、Journal of Endocrinology、Toxicology、Journal of Molecular Endocrinology、Scientific Reports、中国药理学与毒理学杂志和毒理学杂志等审稿专家。

 

2. 教育经历

2011/09 – 2015/06，安徽医科大学，儿少卫生与妇幼保健学，博士研究生

2006/09 – 2009/06，安徽医科大学，卫生毒理学专业，硕士研究生

1999/09 – 2004/06，安徽医科大学，预防医学专业（妇幼保健学方向），本科生

 

3. 主持与参加科研项目

[1] 国家自然科学基金面上项目，81473016，胎盘内质网应激在镉诱发胎儿生长受限中的作用及其分子机理, 2015/01-2018/12，70万元，在研，主持。

[2] 安徽省人才项目，公共卫生与预防医学，2018/01-2020/12，50万元，主持。

[3] 安徽省高校优秀青年人才支持计划重点项目，2015，预防医学。

[4] 安徽省转化医学研究院科研基金项目，2017zhyx22，N-乙酰半胱氨酸和氯喹联合处理对环境应激所致胎儿生长受限的保护效应研究，2018/01-2020/12，20万元，在研，主持；

[5] 国家自然科学基金青年项目，30901217，一氧化氮引起的Notch 信号下调在细菌脂多糖致畸中的作用，2010/01-2012/12，20万元，已结题，主持。

[6] 国家自然科学基金重点项目，81630084，孕期维生素D缺乏与胎儿生长受限的关联及其作用机制, 2017/01-2021/12，275万元，在研，主要参加者（排名第2）。

[7] 国家自然科学基金面上项目，81471467，胎盘内质网应激在LPS诱发胎儿宫内生长受限中的作用, 2015/01-2018/12，74万元，在研，主要参加者。

 

4. 发表SCI论文（#为共同第一作者）

[35] Wang H, Ni HM, Chao X, Ma X, Rodriguez YA, Chavan H, Wang S, Krishnamurthy P, Dobrowsky R, Xu DX, Jaeschke H, Ding WX. Double Deletion of PINK1 and Parkin Impairs Hepatic Mitophagy and Exacerbates Acetaminophen-Induced Liver Injury in Mice. Redox Biol 2019; doi.org/10.1016/j.redox.2019.101148.

[34] Wang H, Li J, Zhang X, Zhu P, Hao JH, Tao FB, Xu DX.Maternal serum arsenic level during pregnancy is positively associated with adverse pregnant outcomes in a Chinese population.Toxicol Appl Pharmacol 2018; 356: 114-119.

[33] Hu J, Wang H (通讯作者), Hu YF, Xu XF, Chen YH, Xia MZ, Zhang C, Xu DX. Cadmium induces inflammatory cytokines through activating Akt signaling in mouse placenta and human trophoblast cells. Placenta 2018; 65: 7-14.

 

 

 

[32] Guo MY, Wang H(通讯作者), Chen YH, Xia MZ, Zhang C, Xu DX. N-acetylcysteine alleviates cadmium-induced placental endoplasmic reticulum stress and fetal growth restriction in mice. PLoS One 2018; 13(1): e0191667.

 

[31] Wang H, Li J, Hao JH, Chen YH, Liu L, Yu Z, Fu L, Tao FB, Xu DX. High serum lead concentration in the first trimester is associated with an elevated risk of small-for-gestational-age infants. Toxicol Appl Pharmacol 2017; 332: 75-80.

[30] Zhang GB, Wang H (通讯作者), Hu J, Guo MY, Wang Y, Zhou Y, Yu Z, Fu L, Chen YH, Xu DX. Cadmium-induced neural tube defects and fetal growth restriction: association with disturbance of placental folate transport. Toxicol Appl Pharmacol 2016; 306: 79-85.

[29] Wang H, Liu L, Hu YF, Hao JH, Chen YH, Su PY, Yu Z, Fu L, Tao FB, Xu DX. Association of maternal serum cadmium level during pregnancy with risk of preterm birth in a Chinese population. Environ Pollut 2016; 216: 851-857.

[28] Wang H, Wang Y, Bo QL, Ji YL, Liu L, Hu YF, Chen YH, Zhang J, Zhao LL, Xu DX. Maternal cadmium exposure reduces placental zinc transport and induces fetal growth restriction in mice. Reprod Toxicol 2016; 63: 174-182.

[27] Wang H, Liu L, Hu YF, Hao JH, Chen YH, Su PY, Fu L, Yu Z, Zhang GB, Wang L, Tao FB, Xu DX.Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study. Sci Rep 2016; 6: 22631.

[26] Wang H, Hu YF, Hao JH, Chen YH, Wang Y, Zhu P, Zhang C, Xu YY, Tao FB, Xu DX. Maternal serum zinc concentration during pregnancy is inversely associated with risk of preterm birth in a Chinese population. J Nutr 2016; 146(3): 509-515.

[25] Wang H（通讯作者）, Yang LL, Ji YL, Chen YH, Hu J, Zhang C, Zhang J, Xu DX*. Different fixative methods influence histological morphology and TUNEL staining in mouse testes. Reprod Toxicol 2016; 60: 53-61.

[24] Wang H, Hu YF, Hao JH, Chen YH, Su PY, Wang Y, Yu Z, Fu L, Xu YY, Zhang C, Tao FB, Xu DX. Maternal zinc deficiency during pregnancy elevates the risks of fetal growth restriction: a population-based birth cohort study. Sci Rep 2015; 5: 11262.

[23]  Wang H, Yang LL, Hu YF, Wang BW, Huang YY, Zhang C, Chen YH, Xu DX. Maternal LPS exposure during pregnancy impairs testicular development, steroidogenesis and spermatogenesis in male offspring. PLoS One 2014; 9(9): e106786.

[22]  Wang H, Ji YL, Wang Q, Zhao XF, Ning H, Liu P, Zhang C, Yu T, Zhang Y, Meng XH, Xu DX. Maternal lead exposure during lactation persistently impairs testicular development and steroidogenesis in male offspring. J Appl Toxicol 2013; 33(12): 1384-1394.

[21]  Wang H, Li L, Zhao M, Chen YH, Zhang ZH, Zhang C, Ji YL, Meng XH, Xu DX. Melatonin alleviates lipopolysaccharide-induced placental cellular stress response in mice. J Pineal Res 2011; 50(4): 418-426.

[20]  Wang H, Wang SF, Ning H#, Ji YL, Zhang C, Zhang Y, Yu T, Ma XH, Zhao XF, Wang Q, Liu P, Meng XH, Xu DX. Maternal cypermethrin exposure during lactation impairs testicular development and spermatogenesis in male mouse offspring. Environ Toxicol 2011, 26(4): 382-394.

[19]  Wang H, Meng XH, Ning H, Zhao XF, Wang Q, Liu P, Zhang H, Zhang C, Chen GH, Xu DX. Age- and gender-dependent impairments of neurobehaviors in mice whose mothers were exposed to lipopolysaccharide during pregnancy. Toxicol Lett 2010; 192(2): 245-251.

[18]  Wang H, Wang Q, Zhao XF, Liu P, Meng XH, Yu T, Ji YL, Zhang H, Zhang C, Zhang Y, Xu DX. Cypermethrin exposure during puberty disrupts testosterone synthesis via downregulating StAR in mouse testes. Arch Toxicol 2010; 84(1): 53-61.

[17]  Wang H, Xu DX, Lu JW, Ning H, Wei W. Melatonin attenuates lipopolysaccharide (LPS)-induced apoptotic liver damage in D-galactosamine-sensitized mice. Toxicology 2007; 237(1-3): 49-57.

[16]  Wang H, Xu DX, Lu JW, Zhao L, Zhang C, Wei W. N-Acetylcysteine attenuates lipopolysaccharide-induced apoptotic liver damage in D-galactosamine-sensitized mice. Acta Pharmacol Sin 2007; 28(11): 1803-1809.

[15] Ji YL#, Wang H#, Zhang C, Zhang Y, Zhao M, Chen YH, Xu DX. N-acetylcysteine protects against cadmium-induced germ cell apoptosis by inhibiting endoplasmic reticulum stress in testes. Asian J Androl 2013; 15(2): 290-296.

[14]  Li J#, Wang H#, Hao JH, Chen YH, Liu L, Yu Z, Fu L, Tao FB, Xu DX. Maternal serum lead level during pregnancy is positively correlated with risk of preterm birth in a Chinese population. Environ Pollut 2017; 227: 484-489.

[13]  Wang Z#, Wang H#, Xu ZM, Ji YL, Chen YH, Zhang ZH, Zhang C, Meng XH, Zhao M, Xu DX. Cadmium-induced teratogenicity: association with ROS-mediated endoplasmic reticulum stress in placenta. Toxicol Appl Pharmacol 2012; 259(2): 236-247.

[12]  Ji YL#, Wang H#, Zhao XF, Wang Q, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX. Crosstalk between endoplasmic reticulum stress and mitochondrial pathway mediates cadmium-induced germ cell apoptosis in testes. Toxicol Sci 2011; 124(2): 446-459.

[11]  Ji YL#, Wang H#, Meng C#, Zhao XF, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX. Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes. J Pineal Res 2012; 52(1): 71-79.

[10]  Ji YL#, Wang H#, Liu P, Wang Q, Zhao XF, Meng XH, Yu T, Zhang H, Zhang C, Zhang Y, Xu DX. Pubertal cadmium exposure impairs testicular development and spermatogenesis via disrupting testicular testosterone synthesis in adult mice. Reprod Toxicol 2010; 29(2): 176-183.

[9]  Zhang H#, Wang H#, Wang Q, Zhao XF, Liu P, Ji YL, Ning H, Yu T, Zhang C, Zhang Y, Meng XH, Xu DX. Pubertal and early adult exposure to fenvalerate disrupts steroidogenesis and spermatogenesis in mice at adulthood. J Appl Toxicol 2010; 30(4): 369-377.

[8]  Zhang H#, Wang H#, Ji YL, Zhang Y, Yu T, Ning H, Zhang C, Zhao XF, Wang Q, Liu P, Xu DX. Maternal fenvalerate exposure during pregnancy persistently impairs testicular development and spermatogenesis in male offspring. Food Chem Toxicol 2010; 48(5): 1160-1169.

[7]  Zhang H#, Wang H#, Ji YL, Ning H, Yu T, Zhang C, Zhang Y, Zhao XF, Wang Q, Liu P, Meng XH, Xu DX. Lactational fenvalerate exposure permanently impairs testicular development and spermatogenesis in mice. Toxicol Lett 2009; 191(1): 47-56.

[6]  Lu JW#, Wang H#, Ji YL, Zhang C, Ning H, Li XY, Zhang H, Duan ZH, Zhao L, Wei W, Xu DX. Differential effects of pyrrolidine dithiocarbamate on TNF-α-mediated liver injury in two different models of fulminant hepatitis. J hepatol 2008; 48(3): 442-452.

[5] Huang YY#, Xia MZ#, Wang H#, Liu XJ, Hu YF, Chen YH, Zhang C, Xu DX.Cadmium selectively induces MIP-2 and COX-2 through PTEN-mediated Akt activation in RAW264.7 cells. Toxicol Sci 2014; 138(2): 310-321.

[4]  Xia MZ#, Liang YL#, Wang H#, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX, Song LH. Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells. J Pineal Res 2012; 53(4): 325-334.

[3]  Ji YL#, Wang Z#, Wang H#, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX. Ascorbic acid protects against cadmium-induced endoplasmic reticulum stress and germ cell apoptosis in testes. Reprod Toxicol 2012; 34(3): 357-363.

[2]  Liu P#, Meng XH#, Wang H#, Ji YL, Zhao M, Zhao XF, Xu ZM, Chen YH, Zhang C, Xu DX. Effects of pubertal fenvalerate exposure on testosterone and estradiol synthesis and the expression of androgen and estrogen receptors in the developing brain. Toxicol Lett 2011; 201(2): 181-189.

[1]  Zhao L#, Chen YH#, Wang H#, Ji YL, Ning H, Zhang C, Lu JW, Duan ZH, Wei LZ, Xu DX. Reactive oxygen species partially contribute to lipopolysaccharide (LPS)-induced teratogenesis in mice. Toxicol Sci 2008; 103(1): 149-157.

 

5. 荣获科技奖励

[1] 王华. 安徽青年****，公共卫生与预防医学，2018年.

[2] 徐德祥、王华、陈远华、陈熙、夏觅真. 松果腺素的抗炎和抗凋亡作用机制. 安徽省人民政府，安徽省科学技术奖（自然科学）一等奖， 2018年.

[3] 王华. 安徽省学术和技术带头人后备人选（第十一批），2017年.

[4] 王华. 中共安徽省委组织部、安徽省人力资源和社会保障厅和安徽省科学技术协会，安徽青年科技奖，2015年；

[5] 徐德祥，姬艳丽，王华，孟秀红，张立. 几种环境化学物的男（雄）性生殖毒性和内分泌干扰效应. 安徽省人民政府，安徽省科学技术奖（自然科学）二等奖， 2015年.

[(6] 徐德祥，王华，姬艳丽，孟秀红，张程，陈远华，赵梅. 生命不同阶段暴露环境内分泌干扰物对男（雄）性生殖发育的损害效应. 中华医学会，中华医学科技奖三等奖，2014年.

[7] 王华，徐德祥，李玲. Melatonin alleviates lipopolysaccharide-induced placental cellular stress response in mice.安徽省科学技术协会、安徽省科学技术厅和安徽省人力资源和保障厅, 安徽省自然科学优秀学术论文一等奖，2013年；

[8] 王华.安徽医科大学首届十佳科技新星，2012年；

[9] 王华, 吕金伟, 徐德祥. Differential effects of pyrrolidine dithiocarbamate on TNF-a-mediated liver injury in two different models of fulminant hepatitis. 安徽省科学技术协会、安徽省科学技术厅和安徽省人力资源和保障厅, 安徽省自然科学优秀学术论文一等奖，2010年；

[10] 王华. 中国药理学会和法国Servier研究院，中国药理学会第十三届Servier青年药理学工作者奖，2009年；

[11] 徐德祥, 魏伟, 陈远华, 王华, 潘和平. 细菌脂多糖对小鼠成年肝脏、小肠、胎盘和胎肝CYP3A的下调作用. 安徽省人民政府, 安徽省科学技术奖（自然科学）二等奖，2009.

[12] 徐德祥，魏伟，张程，王华，陈远华，姬艳丽，王剑萍，李祥云. 细菌脂多糖对孕烷X受体及其靶基因CYP3A 的下调作用. 中华预防医学会，中华预防医学科技奖三等奖，2009年.

[13] 王华. 孕鼠接触细菌脂多糖对胎肝孕烷X受体及其靶基因cyp3a11的调控作用. 中国毒理学会，中国毒理学会首届优秀青年科技人才奖，2007年.