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徐德祥

阅读次数:2467 作者: 王华 发布时间:2018-03-18
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1.简介

  医学博士、二级教授、博士生导师、安徽医科大学学术委员会委员、公共卫生学院副院长、省级教学名师、政府特殊津贴获得者、安徽省跨世纪学术技术带头人、安徽省高校拔尖人才、安徽医科大学环境毒理学实验室负责人。学术兼职:中国毒理学会毒理学教育专委会副主委、中华预防医学学会自由基医学专委会副主委、中华预防医学学会卫生毒理学专委会常委、中国妇幼健康研究会母胎医学专委会委员、中国毒理学会免疫毒理学专委会常委、中国毒理学会生殖毒理学专委会委员、中国环境诱变剂学会理事、安徽省环境诱变剂学会理事长。研究方向:发育与生殖毒理学;主要研究领域:环境有害因素对雄性生殖内分泌的损害效应和机制,孕期环境有害因素暴露对胚胎和胎儿发育的损害效应和机制。科学项目和成果:主持国家自然基金重点项目1项、重大专项(大气细颗粒物的毒理与健康效应)1项、面上项目6项;以通讯作者发表SCI论文97篇;获安徽省科学技术一等奖1项、二等奖2项、三等奖1项;获中华医学科技奖2项;获中华预防医学科技奖1项;2014~2017连续4年入选“药理学与毒理学”ELSEVIER中国高被引学者榜。

 

2.教育经历

2001/07-2004/06,安徽医科大学,药理学专业,博士研究生

1986/09-1989/07,复旦大学医学院,劳动卫生与职业病专业,硕士研究生

1979/09-1984/07,复旦大学医学院,预防医学专业,本科生

 

3.主持科研项目

[1] 国家自然科学基金重点项目,81630084,孕期维生素D缺乏与胎儿生长受限的关联及其机制研究,在研,主持人。

[2] 国家自然科学基金重大专项,91743105,孕期1-硝基芘暴露与胎儿宫内生长受限的关联及其毒理学机制,在研,主持人。

[3] 国家自然科学基金面上项目,81373495,Toll样受体4在对乙酰氨基酚肝损伤不同阶段肝细胞程序性坏死和再生中的作用,已结题,主持人。

[4] 国家自然科学基金面上项目,81172711,活性氧和一氧化氮介导的胎盘内质网应激在LPS致畸中的作用,已结题,主持人。

[5] 国家自然科学基金面上项目,ROS、PGs、NO和TNF-αLPS调控肝细胞LXR-α及其靶基因中的作用,已结题,主持人。

[6] 国家自然科学基金面上项目,30671786,Toll样受体信号通路下游分子ROS、PGs、NO和TNF-α在LPS致畸中的作用,已结题,主持人。

[7] 国家自然科学基金面上项目,细菌脂多糖对肝细胞孕烷X受体及其靶基因CYP3A的下调作用及其机理,已结题,主持人。

[8] 国家自然科学基金面上项目,ROS、PGs和TLR-4在LPS下调肝细胞CYP3A基因表达中的作用,已结题,主持人。

 

4.代表性SCI论文(*通讯作者)

[1] Zhang J, Wang Y, Fu L, Feng YJ, Ji YL, Wang H, Xu DX*. Subchronic cadmium exposure upregulates the mRNA level of genes associated to hepatic lipid metabolism in adult female CD1 mice. Journal of Applied Toxicology, 2018.

[2] Chen YH, Fu L, Hao JH, Wang H, Zhang C, Tao FB*, Xu DX*. Influent factors of gestational vitamin D deficiency and its relation to an increased risk of preterm delivery in Chinese population.Scientific Reports, 8(1):3608, 2018.

[3] Chen YH, Tao FB, Xu DX*. The Association between Pre-pregnancy Body Mass Index and Risk of Preterm Delivery in Chinese Population. American journal of epidemiology, 187: 1123-1124, 2018.

[4] Guo MY, Wang H, Chen YH, Xia MZ, Zhang C, Xu DX*. N-acetylcysteine alleviates cadmium-induced placental endoplasmic reticulum stress and fetal growth restriction in mice. PloSOne, 13(1): 0191667, 2018.

[5] Zhang DG, Zhang C, Wang JX, Wang BW, Wang H, Zhang ZH, Chen YH, Lu Y, Tao L, Wang JQ, Chen X*, Xu DX*. Obeticholic acid protects against carbon tetrachloride-induced acute liver injury and inflammation. Toxicology and applied pharmacology, 314: 39-47, 2017.

[6] Wang JX, Zhang C, Fu L, Zhang DG, Wang BW, Zhang ZH, Chen YH, Lu Y, Chen X*, Xu DX*. Protective effect of rosiglitazone against acetaminophen-induced acute liver injury is associated with down-regulation of hepatic NADPH oxidases. Toxicology letters, 265: 38-46, 2017.

[7] Shen R, Zhao LL, Yu Z, Zhang C, Chen YH, Wang H, Zhang ZH, Xu DX*. Maternal di-(2-ethylhexyl) phthalate exposure during pregnancy causes fetal growth restriction in a stage-specific but gender-independent manner. Reproductive toxicology (Elmsford, N. Y.), 67: 117-124, 2017.

[8] Zhou Y, Chen YH, Fu L, Yu Z, Xia MZ, Hu XG, Wang H, Xu DX*. Vitamin D3 pretreatment protects against lipopolysaccharide-induced early embryo loss through its anti-inflammatory effects. American journal of reproductive immunology (New York, N.Y.: 1989), 77(3), 2017.

[9] Lu Y, Zhang C, Chen YH, Wang H, Zhang ZH, Chen X*, Xu DX*. Immature mice are more susceptible than adult mice to acetaminophen-induced acute liver injury. Scientific reports, 7: 42736, 2017.

[10] Wang B, Liu JJ, Wang Y, Fu L, Shen R, Yu Z, Wang H, Chen YH, Zhang C, Meng XH*, Xu DX*. Maternal Fenvalerate Exposure Induces Fetal Intrauterine Growth Restriction Through Disrupting Placental Thyroid Hormone Receptor SignalingToxicologicalsciences : an official journal of the Society of Toxicology, 157(2): 377-386, 2017.

[11] Xie DD, Chen YH, Xu S, Zhang C, Wang DM, Wang H, Chen L, Zhang ZH, Xia MZ, Xu DX*, Yu DX*. Low vitamin D status is associated with inflammation in patients with prostate cancer. Oncotarget, 8(13): 22076-22085, 2017.

[12] Li J, Wang H, Hao JH, Chen YH, Liu L, Yu Z, Fu L, Tao FB*, Xu DX*. Maternal serum lead level during pregnancy is positively correlated with risk of preterm birth in a Chinese population. Environmental pollution (Barking, Essex: 1987), 227: 484-489, 2017.

[13] Fu L, Chen YH, Xu S, Ji YL, Zhang C, Wang H, Yu DX, Xu DX*. Vitamin D deficiency impairs testicular development and spermatogenesis in mice. Reproductive toxicology (Elmsford, N.Y.), 73: 241-249, 2017.

[14] Fu L, Chen YH, Chen X, Xu S, Yu Z, Xu DX*. Vitamin D deficiency impairs neurobehavioral development in male mice. Physiology & behavior, 179: 333-339, 2017.

[15] Wang H, Li J, Hao JH, Chen YH, Liu L, Yu Z, Fu L, Tao FB*, Xu DX*. High serum lead concentration in the first trimester is associated with an elevated risk of small-for-gestational-age infants. Toxicology and applied pharmacology, 332: 75-80, 2017.

[16] Zhang ZH, Xie DD, Xu S,Xia MZ, Zhang ZQ, Geng H, Chen L, Wang DM, Wei W, Yu DX*, Xu DX*. Total glucosides of paeony inhibits lipopolysaccharide-induced proliferation, migration and invasion in androgen insensitive prostate cancer cells. PloSOne, 12(8): e0182584, 2017.

[17] Chen YH, Hu XG, Zhou Y, Yu Z, Fu L, Zhang GB, Bo QL, Wang H, Zhang C, Xu DX*. Obeticholic Acid Protects against Lipopolysaccharide-Induced Fetal Death and Intrauterine Growth Restriction through Its Anti-Inflammatory Activity. Journal of Immunology, 197(12): 4762-4770,2016.

[18] Zhang ZH, Liu XQ, Zhang C, He W, Wang H, Chen YH, Liu XJ, Chen X*, Xu DX*. Tlr4-mutant mice are resistant to acute alcohol-induced sterol-regulatory element binding protein activation and hepatic lipid accumulation. Scientific Reports, 2016; 6:33513.

[19] Wang H, Liu L, Hu YF, Hao JH, Chen YH, Su PY, Fu L, Yu Z, Zhang GB, Wang L, Tao FB*, Xu DX*. Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study. Scientific Reports, 6:22631, 2016.

[20] Bo QL, Chen YH, Yu Z, Fu L, Zhou Y, Zhang GB, Wang H, Zhang ZH, Xu DX*. Rosiglitazone pretreatment protects against lipopolysaccharide-induced fetal demise through inhibiting placental inflammation. Molelular&Cell Endocrinology, 423: 51-59, 2016.

[21] Wang H, Hu YF, Hao JH, Chen YH, Wang Y, Zhu P, Zhang C, Xu YY, Tao FB*, Xu DX*. Maternal serum zinc concentration during pregnancy is inversely associated with risk of preterm birth in a Chinese population. Journal of Nutrition, 146: 509-515, 2016.

[22] Wang H, Yang LL, Ji YL, Chen YH, Hu J, Zhang C, Zhang J, Xu DX*. Different fixative methods influence histological morphology and TUNEL staining in mouse testes. Reproductive Toxicology, 60: 53-61, 2016.

[23] Tan ZX, Chen YH, Xu S, Qin HY, Wang H, Zhang C, Xu DX*, Zhao H. Calcitriol inhibits tumor necrosis factor alpha and macrophage inflammatory protein-2 during lipopolysaccharide-induced acute lung injury in mice. Steroids 112,81-87,2016.

[24] Wang H, Wang Y, Bo QL, Ji YL, Liu L, Hu YF, Chen YH, Zhang J, Zhao LL, Xu DX*. Maternal cadmium exposure reduces placental zinc transport and induces fetal growth restriction in mice. Reproductive Toxicology,63,174-182,2016.

[25] Wang H, Liu L, Hu YF, Hao JH, Chen YH, Su PY, Yu Z, Fu L, Tao FB, Xu DX*. Association of maternal serum cadmium level during pregnancy with risk of preterm birth in a Chinese population. Environmental Pollution,216: 851-857,2016.

[26] Tan ZX, Chen YH, Xu S, Qin HY, Zhang C, Zhao H*, Xu DX*. Calcitriol inhibits bleomycin-induced early pulmonary inflammatory response and epithelial-mesenchymal transition in mice. Toxicology Letters, 240:161-171, 2016.

[27] Huang JH, Zhang C, Zhang DG, Li L, Chen X, Xu DX. Rifampicin-Induced Hepatic Lipid Accumulation: Association with Up-Regulation of Peroxisome Proliferator-Activated Receptor γ in Mouse Liver. PloS one, 11(11): e0165787, 2016.

[28] Zhang GB, Wang H, Hu J, Guo MY, Wang Y, Zhou Y, Yu Z, Fu L, Chen YH, Xu DX*. Cadmium-induced neural tube defects and fetal growth restriction: Association with disturbance of placental folate transport. Toxicology & Applied Pharmacology 306: 79-85, 2016.

[29] Xu S, Chen YH, Tan ZX, Xie DD, Zhang C, Zhang ZH, Wang H, Zhao H, Yu DX*, Xu DX*. Vitamin D3 pretreatment regulates renal inflammatory responses during lipopolysaccharide-induced acute kidney injury. Scientific Reports, 5: 18687, 2015.

[30] Xu S, Chen YH, Tan ZX, Xie DD, Zhang C, Xia MZ, Wang H, Zhao H, Xu DX*, Yu DX*. Vitamin D3 pretreatment alleviates renal oxidative stress in lipopolysaccharide-induced acute kidney injury. Journal of Steroid Biochemistry & Molecular Biology, 152: 133-141, 2015.

[31] Zhao H, Qin HY, Cao LF, Chen YH, Tan ZX, Zhang C, Xu DX. Phenylbutyric acid inhibits epithelial-mesenchymal transition during bleomycin-induced lung fibrosis. Toxicology letters, 232(1): 213-220, 2015.

[32] Wang H, Hu YF, Hao JH, Chen YH, Su PY, Wang Y, Yu Z, Fu L, Xu YY, Zhang C, Tao FB*, Xu DX*. Maternal zinc deficiency during pregnancy elevates the risks of fetal growth restriction: a population-based birth cohort study. Scientific Reports, 5: 11262, 2015.

[33] Chen YH, Fu L, Hao JH, Yu Z, Zhu P, Wang H, Xu YY, Zhang C, Tao FB*, Xu DX*. Maternal vitamin D deficiency during pregnancy elevates the risks of small for gestational age and low birth weight infants in Chinese population. Journal of Clinical Endocrinology & Metabolism, 100: 1912-1919, 2015.

[34]  Chen YH, Yu Z, Fu L, Wang H, Chen X, Zhang C, Lv ZM, Xu DX*.Vitamin D3 inhibits lipopolysaccharide-induced placental inflammation through reinforcing interaction between vitamin D receptor and nuclear factor kappa B p65 subunit. Scientific Reports, 5: 10871, 2015.

[35]  Liu XJ, Wang BW, Zhang C, Xia MZ, Chen YH, Hu CQ, Wang H, Chen X, Xu DX*. Vitamin d deficiency attenuates high-fat diet-induced hyperinsulinemia and hepatic lipid accumulation in male mice. Endocrinology, 156: 2103-2113, 2015.

[36]  Chen YH, Yu Z, Fu L, Xia MZ, Zhao M, Wang H, Zhang C, Hu YF, Tao FB*, Xu DX*. Supplementation with vitamin D3 during pregnancy protects against lipopolysaccharide- induced neural tube defects through improving placental folate transportation. Toxicological Sciences, 145: 90-97, 2015.

[37] Huang YY, Xia MZ, Wang H, Liu XJ, Hu YF, Chen YH, Zhang C, Xu DX*. Cadmium selectively induces MIP-2 and COX-2 through PTEN-mediated Akt activation in RAW264.7 cells. Toxicological Sciences, 138: 310-321, 2014.

[38] Zhang YF, He W, Zhang C, Liu XJ, Lu Y, Wang H, Zhang ZH, Chen X*, Xu DX*. Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice. Toxicology Letters,225(3): 445-453, 2014.

[39] Zhao M, Chen YH, Chen X, Dong XT, Zhou J, Wang H, Wu SX, Zhang C, Xu DX*. Folic acid supplementation during pregnancy protects against lipopolysaccharide-induced neural tube defects in mice. Toxicology Letters, 224, 201-208, 2014.

[40] Wang H, Yang LL, Hu YF, Wang BW, Huang YY, Zhang C, Chen YH, Xu DX*. Maternal LPS exposure during pregnancy impairs testicular development, steroidogenesis and spermatogenesis in male offspring. PLoS One, 9: e106786, 2014.

[41] Liu XJ, Wang BW, Zhao M, Zhang C, Chen YH, Hu CQ, Zhao H, Wang H, Chen X, Tao FB*, Xu DX*. Effects of maternal LPS exposure during pregnancy on metabolic phenotypes in female offspring. PLoS One, 9: e114780, 2014.

[42] Fu L, Yu Z, Chen YH, Xia MZ, Wang H, Zhang C, Tao FB*, Xu DX*. Orally administered melatonin prevents lipopolysaccharide-induced neural tube defects in mice. PLoS One, 9: e113763, 2014.

[43] Wang H, Yang LL, Hu YF, Wang BW, Huang YY, Zhang C, Chen YH, Xu DX*. Maternal LPS exposure during pregnancy impairs testicular development, steroidogenesis and spermatogenesis in male offspring. PLoS One 9: e106786, 2014.

[44] Zhao M, Chen YH, Dong XT, Zhou J, Chen X, Wang H, Wu SX, Xia MZ, Zhang C, Xu DX*. Folic acid protects against lipopolysaccharide-induced preterm delivery and intrauterine growth restriction through its anti-inflammatory effect in mice. PLoS One, 8, e82713, 2013.

[45] Ji YL, Wang H, Zhang C, Zhang Y, Zhao M, Chen YH, Xu DX*. N-acetylcysteine protects against cadmium-induced germ cell apoptosis by inhibiting endoplasmic reticulum stress in testes. Asian Journal of Andrology, 15, 290-296, 2013. 

[46] Wang JQ, Chen X, Zhang C, Tao L, Zhang ZH, Liu XQ, Xu YB, Wang H, Li J*, Xu DX*. Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice. Toxicology & Applied Pharmacology, 266, 307-316, 2013.

[47] Wang H, Ji YL, Wang Q, Zhao XF, Ning H, Liu P, Zhang C, Yu T, Zhang Y, Meng XH, Xu DX*. Maternal lead exposure during lactation persistently impairs testicular development and steroidogenesis in male offspring. Journal Applied Toxicology, 33: 1384-1394, 2013.

[48] Chen YH, Zhao M, Chen X, Zhang Y, Wang H, Huang YY, Wang Z, Zhang ZH, Zhang C, Xu DX*. Zinc supplementation during pregnancy protects against lipopolysaccharide-induced fetal growth restriction and demise through its anti-inflammatory effect. Journal of Immunology, 189, 454-463, 2012.

[49] Liang YL, Zhang ZH, Liu XJ, Liu XQ, Tao L, Zhang YF, Wang H, Zhang C, Chen X*, Xu DX*. Melatonin protects against apoptosis-inducing factor (AIF)-dependent cell death during acetaminophen-induced acute liver failure. PLoS One, 7, e51911, 2012.

[50] Ji YL, Wang Z, Wang H, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX*. Ascorbic acid protects against cadmium-induced endoplasmic reticulum stress and germ cell apoptosis in testes. Reproductive Toxicology, 34,357-363, 2012.

[51] Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX*, Song LH*. Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells. Journal of Pineal Research 53, 325-334, 2012.

[52] Ji YL, Wang H, Meng C, Zhao XF, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX*. Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes. Journal of Pineal Research, 52, 71-79,2012.

[53]  Wang Z, Wang H, Xu ZM, Ji YL, Chen YH, Zhang ZH, Zhang C, Meng XH, Zhao M, Xu DX*. Cadmium-induced teratogenicity: Association with ROS-mediated endoplasmic reticulum stress in placenta. Toxicology & Applied Pharmacology, 259, 236-247, 2012.

[54] Zhang C, Chen X, Zhu RM, Zhang Y, Yu T, Wang H, Zhao H, Zhao M, Ji YL, Chen YH, Meng XH, Wei W*, Xu DX*. Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice. Toxicology Letters 212, 229-240, 2012.

[55] Chen X, Zhang C, Zhao M, Shi CE, Zhu RM, Wang H, Zhao H, Wei W, Li JB, Xu DX*. Melatonin alleviates lipopolysaccharide-induced hepatic SREBP-1c activation and lipid accumulation in mice. Journal of Pineal Research, 51, 416-425, 2011.

[56] Wang H, Li L, Zhao M, Chen YH, Zhang ZH, Zhang C, Ji YL, Meng XH, Xu DX*. Melatonin alleviates lipopolysaccharide-induced placental cellular stress response in mice.Journal of Pineal Research, 50, 418-426, 2011.

[57]  Ji YL, Wang H, Zhao XF, Wang Q, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX*. Crosstalk between endoplasmic reticulum stress and mitochondrial pathway mediates cadmium-induced germ cell apoptosis in testes. Toxicological Sciences, 124, 446-459, 2011.

[58]  Zhao XF, Wang Q, Ji YL, Wang H, Liu P, Zhang C, Zhang Y, Xu DX*.Fenvalerate induces germ cell apoptosis in mouse testes through the Fas/FasL signaling pathway. Archivesof Toxicology, 85, 1101-1108,2011.

[59] Liu P, Meng XH, Wang H, Ji YL, Zhao M, Zhao XF, Xu ZM, Chen YH, Zhang C, Xu DX*. Effects of pubertal fenvalerate exposure on testosterone and estradiol synthesis and the expression of androgen and estrogen receptors in the developing brain. Toxicology Letters, 201, 181-189, 2011.

[60] Ji YL, Wang H, Liu P, Zhao XF, Zhang Y, Wang Q, Zhang H, Zhang C, Duan ZH, Meng C, Xu DX*. Effects of maternal cadmium exposure during late pregnant period on testicular steroidogenesis in male offspring. Toxicology Letters, 205, 69-78, 2011.

[61] Meng XH, Liu P, Wang H, Zhao XF, Xu ZM, Chen GH, Xu DX*. Gender-specific impairments on cognitive and behavioral development in mice exposed to fenvalerate during puberty. Toxicology Letters, 203, 245-251, 2011.

[62] Chen GH*, Wang H, Yang QG, Tao F, Wang C, Xu DX*.Acceleration of age-related learning and memory decline in middle-aged CD-1 mice due to maternal exposure to lipopolysaccharide during late pregnancy.Behavioral Brain Research, 218, 267-279, 2011.

[63] Wang H, Wang SF, Ning H, Ji YL, Zhang C, Zhang Y, Yu T, Ma XH, Zhao XF, Wang Q, Liu P, Meng XH, Xu DX*. Maternal cypermethrin exposure during lactation impairs testicular development and spermatogenesis in male mouse offspring. Environmental Toxicology, 26, 382-394, 2011.

[64] Chen X, Xu J, Zhang C, Yu T, Wang H, Zhao M, Duan ZH, Zhang Y, Xu JM, Xu DX*. The protective effects of ursodeoxycholic acid on isoniazid plus rifampicin induced liver injury in mice. Euripean Journal of Pharmacology, 659, 53-60, 2011.

[65] Wang H, Meng XH, Ning H, Zhao XF, Wang Q, Liu P, Zhang H, Zhang C, Chen GH*, Xu DX*. Age- and gender-dependent impairments of neurobehaviors in mice whose mothers were exposed to lipopolysaccharide during pregnancy. Toxicology Letters, 192, 245-251, 2010.

[66] Wang H, Wang Q, Zhao XF, Liu P, Meng XH, Yu T, Ji YL, Zhang H, Zhang C, Zhang Y, Xu DX*. Cypermethrin Exposure during Puberty Disrupts Testosterone Synthesis via Downregulating StAR in Mouse Testes.Archives of Toxicology, 84, 53-61, 2010.

[67] Zhang H, Wang H, Wang Q, Zhao XF, Liu P, Ji YL, Ning H, Yu T, Zhang C, Zhang Y, Meng XH, Xu DX*. Pubertal and early adult exposure to fenvalerate disrupts steroidogenesis and spermatogenesis in mice at adulthood. Journal of Applied Toxicology, 30, 369-377,2010.

[68] Wang Q, Zhao XF, Ji YL, Wang H, Liu P, Zhang C, Zhang Y, Xu DX*. Mitochondrial signaling pathway is also involved in bisphenol A induced germ cell apoptosis in testes. Toxicology Letters, 199, 129-135, 2010.

[69] Zhang H, Wang H, Ji YL, Zhang Y, Yu T, Ning H, Zhang C, Zhao XF, Wang Q, Liu P, Xu DX*. Maternal fenvalerate exposure during pregnancy persistently impairs testicular development and spermatogenesis in male offspring. Food Chemistry & Toxicology, 48, 1160-1169, 2010.

[70] Ji YL, Wang H, Liu P, Wang Q, Zhao XF, Meng XH, Yu T, Zhang H, Zhang C, Zhang Y, Xu DX*. Pubertal cadmium exposure impairs testicular development and spermatogenesis via disrupting testicular testosterone synthesis in adult mice. Reproductive Toxicology,29, 176-183, 2010.

[71] Chen X, Zhang C, Wang H, Xu J, Duan ZH, Zhang Y, Yu T, Wei W, Xu DX*, Xu JM*. Altered integrity and decreased expression of hepatocyte tight junctions in rifampicin-induced cholestasis in mice. Toxicology & Applied Pharmacology, 240, 26-36, 2009.

[72] Huang F, Ning H, Xin QQ, Huang Y, Wang H, Zhang ZH, Xu DX, Ichihara G, Ye DQ. Melatonin pretreatment attenuates 2-bromopropane-induced testicular toxicity in rats. Toxicology. 256, 75-82, 2009.

[73] Zhang H, Wang H, Ji YL, Ning H, Yu T, Zhang C, Zhang Y, Zhao XF, Wang Q, Liu P, Meng XH, Xu DX*. Lactational fenvalerate exposure permanently impairs testicular development and spermatogenesis in mice. Toxicology Letters, 191, 47-56, 2009.

[74] Lu JW, WangH, Ji YL, Zhang C, Ning H, Li XY, Zhang H, Duan ZH, Zhao L, Wei W, Xu DX*. Differential effects of pyrrolidine dithiocarbamate on TNF-α-mediated liver injury in two different models of fulminant hepatitis. Journal of Hepatology, 48,442-452,2008.

[75] Zhao L, Chen YH, Wang H, Ji YL, Ning H, Wang SF, Zhang C, Lu JW, Duan ZH, Xu DX*. Reactive oxygen species partially contribute to lipopolysaccharide (LPS)-induced teratogenesis in mice. Toxicological Sciences, 103, 149-157, 2008.

[76] Ning H, Wang H, Zhao L, Zhang C, Li XY, Chen YH, Xu DX*. Maternally administered lipopolysaccharide (LPS) stimulates tumor necrosis factor alpha in fetal liver and fetal brain: its supression by low-dose LPS pretreatment. Toxicology Letters, 176,13-19, 2008.

[77] Li XY, Zhang C, Wang SF, Ji YL, Wang H, Zhao L, Xu DX*. Maternally-administered lipopolysaccharide (LPS) upregulates the expression of heme oxygenase-1 in fetal liver: the role of reactive oxygen species.Toxicology Letters, 176, 169-177, 2008.

[78] Li XY, Zhang C, Wang H, Ji YL, Wang SF, Zhao L, Chen X, Xu DX*. Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced downregulation of CYP3A in fetal liver: its repression by a low dose LPS pretreatment.Toxicology Letters, 179, 71-77, 2008.

[79] Xu DX*, Wang H, Ning H, Zhao L, Chen YH. Maternally administered melatonin differentially regulates lipopolysaccharide (LPS)-induced proinflammatory and antiinflammatory cytokines in maternal serum, amniotic fluid, fetal liver and fetal brain. Journal of Pineal Research, 43, 74-79, 2007.

[80] Wang H, Xu DX*, Lv JW, Ning H, Wei W*. Melatonin attenuates lipopolysaccharide (LPS)-induced apoptotic liver damage in D-galactosamine -sensitized mice. Toxicology, 237, 49-57, 2007.

[81] Wang H, Xu DX*, Lu JW, Zhao L, Zhang C, Wei W*. N-Acetylcysteine attenuates lipopolysaccharide-induced apoptotic liver damage in D-galactosamine-sensitized mice. Acta PharmacologySinica, 28, 1803-1809, 2007.

[82] Xu DX*, Wang H, Zhao L, Ning H, Chen YH, Zhang C . Effects of Low-dose lipopolysaccharide (LPS) pretreatment on LPS-induced intra-uterine fetal death and preterm labor. Toxicology, 234, 167-175, 2007.

[83] Zhang C, Li XY, Zhao L, Wang H, Xu DX*. Lipopolysaccharide (LPS) up-regulates the expression of haem oxygenase-1 in mouse placenta. Placenta 28, 951-957, 2007.

[84] Chen YH, Xu DX*, Wang JP, Wang H, Wei LZ, Sun MF, Wei W. Melatonin protects against lipopolysaccharide-induced intra-uterine fetal death and growth retardation in mice. Journal of Pineal Research, 40, 40-47, 2006.

[85] Chen YH, Xu DX*, Zhao L, Wang H, Wang JP, Wei W. Ascorbic acid protects against lipopolysaccharide-induced intra-uterine fetal death and intra-uterine growth retardation in mice. Toxicology, 217, 39-45,2006.

[86] Xu DX*, Chen YH, Wang H,Zhao L, Wang JP, Wei W*. Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced intra-uterine fetal growth restriction and skeletal development retardation in mice. Toxicology Letters, 163, 20-29, 2006.

[87] Xu DX*,Wang JP, Sun MF, Chen YH, Wei W. Lipopolysaccharide down-regulates the expressions of intestinal pregnane X receptor and cytochrome P450 3a11. European Journal of Pharmacology, 536, 162-170, 2006.

[88] Wang AL, Wang JP, Wang H, ChenYH, Zhao L, Wang LS, Wei W*, Xu DX*. A dual effect of N-acetylcysteine on acute ethanol-induced liver damage in mice. Hepatology Research, 34, 199-206,2006.

[89] Xu DX*, Chen YH, Zhao L, Wang H, Wei W. Reactive oxygen species are involved in lipopolysaccharide-induced intra-uterine growth restriction and skeletal developmentretardation in mice. American Journal ofObstetrics & Gynecology, 195, 1707-1714, 2006.

[90] Xu DX*, Wei W*, Sun MF, Wei LZ, Wang JP. Melatonin counteracts against LPS-induced oxidative stress and attenuates LPS-induced down-regulation of nuclear receptor pregnane X receptor and its target gene CYP3A in mouse liver. Journal of Pineal Research,38,27-34, 2005.

[91] Xu DX*, Chen YH, Wang H, Zhao L, Wang JP, Wei W. Effect of N-acetylcysteine on lipopolysaccharide-induced intra-uterine fetal death and intra-uterine growth retardation in mice. Toxicological Sciences, 88, 525-533, 2005.

[92] Xu DX*, Chen YH, Wang JP, Sun MF, Wang H, Wei LZ, Wei W. Perinatal lipopolysaccharide exposure downregulates pregnane X receptor and cyp3a11 expression in fetal mouse liver. Toxicological Sciences, 87,38-45, 2005.

[93] Wang JP, Xu DX*, Sun MF, Chen YH, Wang H, Wei W. Chronic Ethanol Exposure Downregulates Hepatic Expression of Pregnane X Receptor and P450 3A11 in Female ICR Mice. Toxicology, 215, 234-244, 2005.

[94] Chen YH, Wang JP, Wang H, Sun MF, Wei LZ, Wei W, Xu DX*. Lipopolysaccharide treatment downregulates the expression of the pregnane X receptor, cyp3a11 and mdr1a genes in mouse placenta.Toxicology, 211,242-252, 2005.

[95] Xu DX*, Wei W*, Sun MF, Wu CY, Wang JP, Wei LZ, Zhou CF. Kupffer cells and ROS partially mediate LPS-induced down-regulation of nuclear receptor pregnane X receptor and its target gene CYP3Ain mouse liver. Free Radical Biology & Medicine, 37,10-22, 2004.

[96] Xu DX*, Zhu QX, Zheng LK, Wang QN, Shen HM, Deng LX, Ong CN. Exposure to acrylonitrile induced DNA strand breakage and sex chromosome aneuploidy in human spermatozoa. Mutation Research 537, 93-100, 2003.

[97] Xu DX*, Shen HM, Zhu QX, Chua L, Wang QN, Chia SE, Ong CN. The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma. Mutation Research, 534,155-163, 2003.

 

5. 省级以上科技奖励

[1] 徐德祥,王华,陈远华,陈熙,夏觅真. 松果腺素的抗炎和抗凋亡作用机制. 安徽省自然科学一等奖. 安徽省人民政府,2017.

[2] 徐德祥,姬艳丽,王华,孟秀红,张立. 几种环境化学物的男(雄)性生殖毒性和内分泌干扰效应. 安徽省自然科学二等奖. 安徽省人民政府,2014.

[3] 徐德祥,王华,姬艳丽,孟秀红,张程,陈远华,赵梅. 生命不同阶段暴露环境内分泌干扰物对男(雄)性生殖发育的损害效应. 中华医学科技奖. 中华医学会,2014.

[4]姬艳丽,徐德祥(导师).生命不同阶段镉暴露对雄性小鼠生殖发育的影响.安徽省优秀博士论文.安徽省人民政府学位委员会. 2013.

[5] Lu JW, WangH, Ji YL, Zhang C, Ning H, Li XY, Zhang H, Duan ZH, Zhao L, Wei W, Xu DX (通讯作者). Differential effects of pyrrolidine dithiocarbamate on TNF-α-mediated liver injury in two different models of fulminant hepatitis. 安徽医科大学十年最具影响力十佳论文(2002-2011). 安徽医科大学,2012.

[6] Chen YH, Zhao M, Chen X, Zhang Y, Wang H, Huang YY, Wang Z, Zhang ZH, Zhang C, Xu DX (通讯作者). Zinc supplementation during pregnancy protects against lipopolysaccharide-induced fetal growth restriction and demise through its anti-inflammatory effect. 安徽医科大学2012年最具影响力十佳论文. 安徽医科大学,2012.

[7]Wang H, Li L, Zhao M, Chen YH, Zhang ZH, Zhang C, Ji YL, Meng XH, Xu DX (通讯作者). Melatonin alleviates lipopolysaccharide-induced placental cellular stress response in mice. 安徽省自然科学优秀论文一等奖. 安徽省科技厅,2012.

[8] Chen X, Zhang C, Zhao M, Shi CE, Zhu RM, Wang H, Zhao H, Wei W, Li JB, Xu DX (通讯作者). Melatonin alleviates lipopolysaccharide-induced hepatic SREBP-1c activation and lipid accumulation in mice.安徽省自然科学优秀论文一等奖. 安徽省科技厅,2012.

[9]王华,徐德祥(导师). 细菌脂多糖诱导小鼠急性凋亡性肝损伤的分子机理. 安徽省优秀硕士学位论文. 安徽省人民政府学位委员会. 2011.

[10] 王华,吕金伟,姬艳丽,张程,宁萑,李祥云,章恒,段自皞,赵磊,魏伟,徐德祥(通讯作者). 二硫代氨基甲酸吡咯烷对细菌脂多糖引起的两种类型急性肝损伤的不同效应. 安徽省自然科学优秀论文一等奖. 安徽省科技厅,2009.

[11] 徐德祥, 王华,宁萑,赵磊,陈远华. 给予母体褪黑素对LPS刺激母鼠血清、羊水、胎肝和胎脑致炎因子和抗炎因子的不同影响. 安徽省自然科学优秀论文一等奖. 安徽省科技厅,2009.

[12] 陈远华,徐德祥(通讯作者), 王剑萍,王华,魏凌珍,孙美芳,魏伟.褪黑素保护细菌脂多糖引起的胎儿死亡和生长发育迟缓. 安徽省自然科学优秀论文一等奖. 安徽省科技厅,2009.

[13] 宁萑,王华,赵磊,陈远华,徐德祥(通讯作者). 低剂量细菌脂多糖预处理抑制母体接触细菌脂多糖诱导胎肝和胎脑中肿瘤坏死因子α释放. 安徽省自然科学优秀论文二等奖. 安徽省科技厅,2009.

[14] 李祥云,张程,王素芳,姬艳丽,王华,赵磊,徐德祥(通讯作者). 活性氧介导母体细菌脂多糖暴露上调胎肝组织血红素氧化酶1的表达. 安徽省自然科学优秀论文二等奖. 安徽省科技厅,2009.

[15] 张程,徐德祥(导师). 孕期母体接触细菌脂多糖上调小鼠胎盘和胎肝血红素氧化酶1表达. 安徽省优秀硕士学位论文. 安徽省人民政府学位委员会. 2009.

[16] 赵磊,陈远华,王华,姬艳丽,宁萑,王素芳,张程,吕金伟,段自皞,魏凌珍,徐德祥(通讯作者). 活性氧在细菌脂多糖致畸中的作用. 安徽省自然科学优秀论文三等奖. 安徽省科技厅,2009.

[17] 徐德祥,魏伟,陈远华,王华,潘和平. 细菌脂多糖对小鼠成年肝脏、小肠、胎盘和胎肝CYP3A的下调作用. 安徽省自然科学二等奖. 安徽省人民政府,2008.

[18] 陈远华,徐德祥(导师). 妊娠晚期接触细菌脂多糖对胎儿生长发育和骨骼发育的影响. 安徽省优秀硕士学位论文. 安徽省人民政府学位委员会. 2008.

[19] 徐德祥,朱启星,陈远华,王华,孙美芳. 建立检测人精子细胞染色体畸变和DNA损伤的试验方法. 安徽省自然科学三等奖. 安徽省人民政府,2007.

[20] 陈远华,王剑萍,王华,孙美芳,魏凌珍,魏伟,徐德祥(通讯作者). 细菌脂多糖对小鼠胎盘pxr及其靶基因cyp3a11mdr1a的下调作用. 安徽省自然科学优秀论文一等奖. 安徽省科技厅,2007.

[21] 徐德祥,沈汉明,朱启星,Chua LH,王取南,Chia SE, Ong CN. 精液镉铅硒浓度与人精子质量和精子DNA氧化损伤的关系. 安徽省自然科学优秀论文一等奖,安徽省科技厅,2007.

[22] 徐德祥,魏伟(导师). 脂多糖对小鼠肝脏孕烷X受体和靶基因CYP3A的下调作用及其部分机制. 全国优秀博士论文提名奖. 国务院学位委员会,2006.

 

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