胎儿产前暴露于宫内感染导致触珠蛋白（haptoglobin, Hp）表达，因此，Catalin S. Buhimschi团队关注到触珠蛋白与新生儿出生结局的关系。该项研究分析了921名早产的新生儿脐带血样本。新生儿按脐带血Hp和IL-6水平分成三组，即inflammation-nonexposed组，inflammation-exposed hp组和inflammation-exposed hypo-hp组。结果发现，inflammation-exposed hypo-hp组相比inflammation-exposed hp组，脑室内出血（95% CI: 1.4–34.6, P= 0.02）和脑瘫（95% CI: 1.7–23.5, P= 0.006）发生率显著升高。以上结果表明，对脐带血进行触珠蛋白检测，可作为加强早产儿监测的措施。
参考文献：Catalin S. Buhimschia, Kathleen A. Jablonskit, Dwight J. Rousec, Michael W. Varnerd, Uma M. Reddyu, Brian M. Mercere f, Kenneth J. Levenog, Ronald J. Wapnerh i, Yoram Sorokinj, John M. Thorp Jrk, Susan M. Raminl, Fergal D. Malonem, Marshall W. Carpentern, Mary J. O'Sullivano, Alan M. Peacemanp, George R. Saadeq, Donald Dudleyr, Steve N. Caritiss, Irina A. Buhimschi. Cord Blood Haptoglobin, Cerebral Palsy and Death in Infants of Women at Risk for Preterm Birth: A Secondary Analysis of a Randomised Controlled Trial, EClinical Medicine, 2019.
撰写人：时雪婷