1.简介

  医学博士，中国毒理学会会员，安徽省预防医学会卫生毒理学专业委员会委员，安徽省环境诱变剂学会理事。研究方向：生殖与发育毒理学。主持国家自然科学青年基金项目（已结题）和面上项目各1项。以第一作者或共同第一作者发表SCI论文7篇，累计被引用100余次，以合作作者发表SCI论文16篇；获中华医学科技三等奖2项(排名第6和第3)、中华预防医学科技三等奖（排名第6）、安徽省自然科学奖二等奖1项（排名第2）、2013年度安徽医科大学十佳科技新星、2014年度安徽省优秀博士论文获得者。

 

2.教育经历

2007/09–2011/06，安徽医科大学，儿少卫生与妇幼保健学专业，博士研究生

2000/09 –2003/06，安徽医科大学，劳动卫生与环境卫生学专业，硕士研究生

1995/09 –2000/06 安徽医科大学，预防医学专业，本科生

 

3.主持科研项目

[1] 国家自然科学基金面上项目，31571557，内质网IRE1信号介导镉诱发睾丸生殖细胞凋亡的机制，在研，主持人。

[2] 国家自然科学基金青年项目，31000664，活性氧介导的内质网应激在镉致小鼠睾丸生殖细胞凋亡和自噬中的作用，已结题，主持人。

 

4.代表性SCI论文（*通讯作者）

[1] Ji YL, Wang H, Zhang C, Zhang Y, Zhao M, Chen YH, Xu DX*. N-acetylcysteine protects against cadmium-induced germ cell apoptosis by inhibiting endoplasmic reticulum stress in testes. Asian Journal of Andrology, 15, 290-296, 2013. 

[2] Ji YL, Wang Z, Wang H, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX*. Ascorbic acid protects against cadmium-induced endoplasmic reticulum stress and germ cell apoptosis in testes. Reproductive Toxicology, 34,357-363, 2012.

[3] Ji YL, Wang H, Meng C, Zhao XF, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX*. Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes. Journal of Pineal Research, 52, 71-79,2012.

[4] Ji YL, Wang H, Zhao XF, Wang Q, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX*. Crosstalk between endoplasmic reticulum stress and mitochondrial pathway mediates cadmium-induced germ cell apoptosis in testes. Toxicological Sciences, 124, 446-459, 2011.

[5] Ji YL, Wang H, Liu P, Zhao XF, Zhang Y, Wang Q, Zhang H, Zhang C, Duan ZH, Meng C, Xu DX*. Effects of maternal cadmium exposure during late pregnant period on testicular steroidogenesis in male offspring. Toxicology Letters, 205, 69-78, 2011.

[6] Ji YL, Wang H, Liu P, Wang Q, Zhao XF, Meng XH, Yu T, Zhang H, Zhang C, Zhang Y, Xu DX*. Pubertal cadmium exposure impairs testicular development and spermatogenesis via disrupting testicular testosterone synthesis in adult mice. Reproductive Toxicology,29, 176-183, 2010.

[7] Zhang J, Wang Y, Fu L, Feng YJ, Ji YL, Wang H, Xu DX*. Subchronic cadmium exposure upregulates the mRNA level of genes associated to hepatic lipid metabolism in adult female CD1 mice. Journal of Applied Toxicology, 2018.

[8] Fu L, Chen YH, Xu S, Ji YL, Zhang C, Wang H, Yu DX, Xu DX*. Vitamin D deficiency impairs testicular development and spermatogenesis in mice. Reproductive toxicology (Elmsford, N.Y.), 73: 241-249, 2017.

[9] Wang H, Yang LL, Ji YL, Chen YH, Hu J, Zhang C, Zhang J, Xu DX*. Different fixative methods influence histological morphology and TUNEL staining in mouse testes. Reproductive Toxicology, 60: 53-61, 2016.

[10] Wang H, Wang Y, Bo QL, Ji YL, Liu L, Hu YF, Chen YH, Zhang J, Zhao LL, Xu DX*. Maternal cadmium exposure reduces placental zinc transport and induces fetal growth restriction in mice. Reproductive Toxicology，63，174-182，2016.

[11] Wang Z, Wang H, Xu ZM, Ji YL, Chen YH, Zhang ZH, Zhang C, Meng XH, Zhao M, Xu DX*. Cadmium-induced teratogenicity: Association with ROS-mediated endoplasmic reticulum stress in placenta. Toxicology & Applied Pharmacology, 259, 236-247, 2012.

[12] Zhang C, Chen X, Zhu RM, Zhang Y, Yu T, Wang H, Zhao H, Zhao M, Ji YL, Chen YH, Meng XH, Wei W*, Xu DX*. Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice. Toxicology Letters 212, 229-240, 2012.

[13] Wang H, Li L, Zhao M, Chen YH, Zhang ZH, Zhang C, Ji YL, Meng XH, Xu DX*. Melatonin alleviates lipopolysaccharide-induced placental cellular stress response in mice. Journal of Pineal Research, 50, 418-426, 2011.

[14] Zhao XF, Wang Q, Ji YL, Wang H, Liu P, Zhang C, Zhang Y, Xu DX*.Fenvalerate induces germ cell apoptosis in mouse testes through the Fas/FasL signaling pathway. Archivesof Toxicology, 85, 1101-1108,2011.

[15] Wang H, Wang SF, Ning H, Ji YL, Zhang C, Zhang Y, Yu T, Ma XH, Zhao XF, Wang Q, Liu P, Meng XH, Xu DX*. Maternal cypermethrin exposure during lactation impairs testicular development and spermatogenesis in male mouse offspring. Environmental Toxicology, 26, 382-394, 2011.

[16] Wang H, Wang Q, Zhao XF, Liu P, Meng XH, Yu T, Ji YL, Zhang H, Zhang C, Zhang Y, Xu DX*. Cypermethrin Exposure during Puberty Disrupts Testosterone Synthesis via Downregulating StAR in Mouse Testes.Archives of Toxicology, 84, 53-61, 2010.

[17] Zhang H, Wang H, Wang Q, Zhao XF, Liu P, Ji YL, Ning H, Yu T, Zhang C, Zhang Y, Meng XH, Xu DX*. Pubertal and early adult exposure to fenvalerate disrupts steroidogenesis and spermatogenesis in mice at adulthood. Journal of Applied Toxicology, 30, 369-377,2010.

[18] Wang Q, Zhao XF, Ji YL, Wang H, Liu P, Zhang C, Zhang Y, Xu DX*. Mitochondrial signaling pathway is also involved in bisphenol A induced germ cell apoptosis in testes. Toxicology Letters, 199, 129-135, 2010.

[19] Zhang H, Wang H, Ji YL, Zhang Y, Yu T, Ning H, Zhang C, Zhao XF, Wang Q, Liu P, Xu DX*. Maternal fenvalerate exposure during pregnancy persistently impairs testicular development and spermatogenesis in male offspring. Food Chemistry & Toxicology, 48, 1160-1169, 2010.

[20] Zhang H, Wang H, Ji YL, Ning H, Yu T, Zhang C, Zhang Y, Zhao XF, Wang Q, Liu P, Meng XH, Xu DX*. Lactational fenvalerate exposure permanently impairs testicular development and spermatogenesis in mice. Toxicology Letters, 191, 47-56, 2009.

[21] Lu JW, WangH, Ji YL, Zhang C, Ning H, Li XY, Zhang H, Duan ZH, Zhao L, Wei W, Xu DX*. Differential effects of pyrrolidine dithiocarbamate on TNF-α-mediated liver injury in two different models of fulminant hepatitis. Journal of Hepatology, 48，442-452，2008.

[22] Zhao L, Chen YH, Wang H, Ji YL, Ning H, Wang SF, Zhang C, Lu JW, Duan ZH, Xu DX*. Reactive oxygen species partially contribute to lipopolysaccharide (LPS)-induced teratogenesis in mice. Toxicological Sciences, 103, 149-157, 2008.

[23] Li XY, Zhang C, Wang SF, Ji YL, Wang H, Zhao L, Xu DX*. Maternally-administered lipopolysaccharide (LPS) upregulates the expression of heme oxygenase-1 in fetal liver: the role of reactive oxygen species.Toxicology Letters, 176, 169-177, 2008.

[24] Li XY, Zhang C, Wang H, Ji YL, Wang SF, Zhao L, Chen X, Xu DX*. Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced downregulation of CYP3A in fetal liver: its repression by a low dose LPS pretreatment.Toxicology Letters, 179, 71-77, 2008.

 

5.省级以上科技奖励

[1] 徐德祥，姬艳丽，王华，孟秀红，张立. 几种环境化学物的男（雄）性生殖毒性和内分泌干扰效应. 安徽省自然科学二等奖. 安徽省人民政府，2014.

[2] 徐德祥，王华，姬艳丽，孟秀红，张程，陈远华，赵梅. 生命不同阶段暴露环境内分泌干扰物对男（雄）性生殖发育的损害效应. 中华医学科技奖. 中华医学会，2014.

[3] 姬艳丽，徐德祥（导师）.生命不同阶段镉暴露对雄性小鼠生殖发育的影响.安徽省优秀博士论文.安徽省人民政府学位委员会. 2013.

[4] 姬艳丽，王华，徐德祥. Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes. 安徽省第八届自然科学优秀论文，安徽省科学技术厅，一等奖，2016。

[5] 姬艳丽，王华，赵显锋，王群，张程，张莹，赵梅，陈远华，孟秀红，徐德祥. Crosstalk between endoplasmic reticulum stress and mitochondrial pathway mediates cadmium-induced germ cell apoptosis in testes. 安徽省第七届自然科学优秀论文，安徽省科学技术厅，二等奖，2013。

[6] Lu JW, WangH, Ji YL, Zhang C, Ning H, Li XY, Zhang H, Duan ZH, Zhao L, Wei W, Xu DX (通讯作者). Differential effects of pyrrolidine dithiocarbamate on TNF-α-mediated liver injury in two different models of fulminant hepatitis. 安徽医科大学十年最具影响力十佳论文(2002-2011). 安徽医科大学，2012.

[7] Wang H, Li L, Zhao M, Chen YH, Zhang ZH, Zhang C, Ji YL, Meng XH, Xu DX (通讯作者). Melatonin alleviates lipopolysaccharide-induced placental cellular stress response in mice. 安徽省自然科学优秀论文一等奖. 安徽省科技厅，2012.

[8] 王华，吕金伟，姬艳丽，张程，宁萑，李祥云，章恒，段自皞，赵磊，魏伟，徐德祥(通讯作者). 二硫代氨基甲酸吡咯烷对细菌脂多糖引起的两种类型急性肝损伤的不同效应. 安徽省自然科学优秀论文一等奖. 安徽省科技厅，2009.

[9] 李祥云，张程，王素芳，姬艳丽，王华，赵磊，徐德祥（通讯作者). 活性氧介导母体细菌脂多糖暴露上调胎肝组织血红素氧化酶1的表达. 安徽省自然科学优秀论文二等奖. 安徽省科技厅，2009.

[10] 赵磊，陈远华，王华，姬艳丽，宁萑，王素芳，张程，吕金伟，段自皞，魏凌珍，徐德祥(通讯作者). 活性氧在细菌脂多糖致畸中的作用. 安徽省自然科学优秀论文三等奖. 安徽省科技厅，2009.