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陈远华

阅读次数:1281 作者: 王华 发布时间:2018-03-28
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1.简介

    医学博士、副教授、安徽省学术技术带头人后备人选。学术兼职:中华预防医学学会自由基医学专委会委员。研究方向:发育毒理学;主要研究领域:宫内暴露环境有害因素对胚胎和胎儿发育的损害效应和机制。科学项目和成果:主持国家自然基金项目2项(其中1项已结题);发表SCI论文68篇,其中以通讯作者或第一作者(含并列)发表SCI论文24篇,平均影响因子>4.0(单篇最高为10.39);获安徽省自然科学类科学技术奖一等奖1项(排名第3)、安徽省自然科学类科学技术奖二等奖和三等奖各1项(均排名第3)、中华医学科技奖三等奖2项(1项排名第31项排名第6)、中华预防医学科技奖三等奖1项(排名第5)、安徽省自然科学优秀学术论文一等奖3项(排名第1)。

 

2. 教育经历

2010/07-2014/06安徽医科大学,儿少卫生与妇幼保健学专业,博士研究生

2004/09-2007/07安徽医科大学,卫生毒理学专业,硕士研究生

1999/09-2004/07安徽医科大学,预防医学专业,本科生

 

3. 主持科研项目

[1] 国家自然科学基金青年基金,30901617,Wnt/β-catenin信号通路在LPS致畸中的作用,已结题,主持人。

[2] 国家自然科学基金面上项目,81471467,胎盘内质网应激在LPS诱发宫内生长受限中的作用,主持人。

 

4. 代表性SCI论文(*通讯作者)

[1] Chen YH, Fu L, Hao JH, Wang H, Zhang C, Tao FB, Xu DX. Influent factors of gestational vitamin D deficiency and its relation to an increased risk of preterm delivery in Chinese population. Scientific Reports, 8(1):3608, 2018.

[2] Chen YH, Tao FB, Xu DX. The Association between Pre-pregnancy Body Mass Index and Risk of Preterm Delivery in Chinese Population. American journal of epidemiology, 2018.

[3] Shen R, Zhao LL, Yu Z, Zhang C, Chen YH*, Wang H, Zhang ZH, Xu DX*. Maternal di-(2-ethylhexyl) phthalate exposure during pregnancy causes fetal growth restriction in a stage-specific but gender-independent manner. Reproductive toxicology (Elmsford, N. Y.), 67: 117-124, 2017.

[4] Zhou Y,Chen YH(co-first author), Fu L, Yu Z, Xia MZ, Hu XG, Wang H, Xu DX*. Vitamin D3 pretreatment protects against lipopolysaccharide-induced early embryo loss through its anti-inflammatory effects. American journal of reproductive immunology (New York, N.Y.: 1989), 77(3), 2017.

[5] Xie DD, Chen YH(co-first author),Xu S, Zhang C, Wang DM, Wang H, Chen L, Zhang ZH, Xia MZ, Xu DX, Yu DX. Low vitamin D status is associated with inflammation in patients with prostate cancer. Oncotarget, 8(13): 22076-22085, 2017.

[6] Yang BB, Chen YH (co-first author), Zhang C, Shi CE, Hu KF, Zhou J, Xu DX, Chen X. Low vitamin D status is associated with advanced liver fibrosis in patients with nonalcoholic fatty liver disease. Endocrine. 2017;55(2):582-590.

[7] Fu L, Chen YH(co-first author),Xu S, Ji YL, Zhang C, Wang H, Yu DX, Xu DX. Vitamin D deficiency impairs testicular development and spermatogenesis in mice. Reproductive toxicology (Elmsford, N.Y.), 73: 241-249, 2017.

[8] Fu L, Chen YH*(co-first author), Chen X, Xu S, Yu Z, Xu DX*. Vitamin D deficiency impairs neurobehavioral development in male mice. Physiology & behavior, 179: 333-339, 2017.

[9] Chen YH, Hu XG, Zhou Y, Yu Z, Fu L, Zhang GB, Bo QL, Wang H, Zhang C, Xu DX. Obeticholic Acid Protects against Lipopolysaccharide-Induced Fetal Death and Intrauterine Growth Restriction through Its Anti-Inflammatory Activity. Journal of Immunology, 197(12): 4762-4770,2016.

[10] Bo QL, Chen YH (co-first author), Yu Z, Fu L, Zhou Y, Zhang GB, Wang H, Zhang ZH, Xu DX. Rosiglitazone pretreatment protects against lipopolysaccharide-induced fetal demise through inhibiting placental inflammation. Molelular&Cell Endocrinology, 423: 51-59, 2016.

[11] Tan ZX, Chen YH (co-first author), Xu S, Qin HY, Wang H, Zhang C, Xu DX, Zhao H. Calcitriol inhibits tumor necrosis factor alpha and macrophage inflammatory protein-2 during lipopolysaccharide-induced acute lung injury in mice. Steroids 112,81-87,2016.

[12] Tan ZX, Chen YH (co-first author),Xu S, Qin HY, Zhang C, Zhao H, Xu DX. Calcitriol inhibits bleomycin-induced early pulmonary inflammatory response and epithelial-mesenchymal transition in mice. Toxicology Letters, 240:161-171, 2016.

[13] Xu S, Chen YH (co-first author), Tan ZX, Xie DD, Zhang C, Zhang ZH, Wang H, Zhao H, Yu DX, Xu DX. Vitamin D3 pretreatment regulates renal inflammatory responses during lipopolysaccharide-induced acute kidney injury. Scientific Reports, 5: 18687, 2015.

[14] Xu S, Chen YH(co-first author), Tan ZX, Xie DD, Zhang C, Xia MZ, Wang H, Zhao H, Xu DX, Yu DX. Vitamin D3 pretreatment alleviates renal oxidative stress in lipopolysaccharide-induced acute kidney injury. Journal of Steroid Biochemistry & Molecular Biology, 152: 133-141, 2015.

[15] Chen YH, Fu L, Hao JH, Yu Z, Zhu P, Wang H, Xu YY, Zhang C, Tao FB, Xu DX. Maternal vitamin D deficiency during pregnancy elevates the risks of small for gestational age and low birth weight infants in Chinese population. Journal of Clinical Endocrinology & Metabolism, 100: 1912-1919, 2015.

[16] Chen YH, Yu Z, Fu L, Wang H, Chen X, Zhang C, Lv ZM, Xu DX.Vitamin D3 inhibits lipopolysaccharide-induced placental inflammation through reinforcing interaction between vitamin D receptor and nuclear factor kappa B p65 subunit. Scientific Reports, 5: 10871, 2015.

[17] Chen YH, Yu Z, Fu L, Xia MZ, Zhao M, Wang H, Zhang C, Hu YF, Tao FB*, Xu DX. Supplementation with vitamin D3 during pregnancy protects against lipopolysaccharide- induced neural tube defects through improving placental folate transportation. Toxicological Sciences, 145: 90-97, 2015.

[18] Zhao M, Chen YH(co-first author), Chen X, Dong XT, Zhou J, Wang H, Wu SX, Zhang C, Xu DX. Folic acid supplementation during pregnancy protects against lipopolysaccharide-induced neural tube defects in mice. Toxicology Letters, 224, 201-208, 2014.

[19] Zhao M, Chen YH(co-first author), Dong XT, Zhou J, Chen X, Wang H, Wu SX, Xia MZ, Zhang C, Xu DX. Folic acid protects against lipopolysaccharide-induced preterm delivery and intrauterine growth restriction through its anti-inflammatory effect in mice. PLoS One, 8, e82713, 2013.

[20] Chen YH, Zhao M, Chen X, Zhang Y, Wang H, Huang YY, Wang Z, Zhang ZH, Zhang C, Xu DX. Zinc supplementation during pregnancy protects against lipopolysaccharide-induced fetal growth restriction and demise through its anti-inflammatory effect. Journal of Immunology, 189, 454-463, 2012.

[21] Zhao L, Chen YH (co-first author), Wang H, Ji YL, Ning H, Wang SF, Zhang C, Lu JW, Duan ZH, Xu DX. Reactive oxygen species partially contribute to lipopolysaccharide (LPS)-induced teratogenesis in mice. Toxicological Sciences, 103, 149-157, 2008.

[22] Chen YH, Xu DX, Wang JP, Wang H, Wei LZ, Sun MF, Wei W. Melatonin protects against lipopolysaccharide-induced intra-uterine fetal death and growth retardation in mice. Journal of Pineal Research, 40, 40-47, 2006.

[23] Chen YH,Xu DX, Zhao L, Wang H, Wang JP, Wei W. Ascorbic acid protects against lipopolysaccharide-induced intra-uterine fetal death and intra-uterine growth retardation in mice. Toxicology, 217, 39-45,2006.

[24] Chen YH, Wang JP, Wang H, Sun MF, Wei LZ, Wei W, Xu DX. Lipopolysaccharide treatment downregulates the expression of the pregnane X receptor, cyp3a11 and mdr1a genes in mouse placenta.Toxicology, 211,242-252, 2005.

 

5. 省级以上科技奖励

[1] 徐德祥,王华,陈远华,陈熙,夏觅真. 松果腺素的抗炎和抗凋亡作用机制. 安徽省自然科学一等奖. 安徽省人民政府2017.

[2] 徐德祥,王华,姬艳丽,孟秀红,张程,陈远华,赵梅. 生命不同阶段暴露环境内分泌干扰物对男(雄)性生殖发育的损害效应. 中华医学科技奖. 中华医学会2014.

[3] 徐德祥, 魏伟, 张程, 王华, 陈远华, 姬艳丽, 宁萑, 李祥云,细菌脂多糖对孕烷X受体及其靶基因CYP3A的下调作用,中华预防医学会,中华预防医学科技奖,三等奖,2009.

[4] 徐德祥, 魏伟, 陈远华, 王华, 潘和平, 张程, 李祥云, 宁萑,细菌脂多糖对小鼠成年肝脏、小肠、胎盘和胎肝CYP3A的下调作用,中华医学会,中华医学科技奖三等奖,2008年.

[5] 徐德祥,魏伟,陈远华,王华,潘和平. 细菌脂多糖对小鼠成年肝脏、小肠、胎盘和胎肝CYP3A的下调作用. 安徽省自然科学二等奖. 安徽省人民政府,2008.

[6] 徐德祥,朱启星,陈远华,王华,孙美芳. 建立检测人精子细胞染色体畸变和DNA损伤的试验方法. 安徽省自然科学三等奖. 安徽省人民政府,2007.

[7] 陈远华,赵梅,徐德祥Zinc supplementation during pregnancy protects against lipopolysaccharide-induced fetal growth restriction and demise through its anti-inflammatory effect.安徽省科技厅,安徽省第八届自然科学优秀学术论文,一等奖2016年.

[8] 陈远华,徐德祥, 王剑萍,王华,魏凌珍,孙美芳,魏伟.褪黑素保护细菌脂多糖引起的胎儿死亡和生长发育迟缓. 安徽省自然科学优秀论文一等奖. 安徽省科技厅,2009.

[9] 陈远华,王剑萍,王华,孙美芳,魏凌珍,魏伟,徐德祥. 细菌脂多糖对小鼠胎盘pxr及其靶基因cyp3a11和mdr1a的下调作用. 安徽省自然科学优秀论文一等奖. 安徽省科技厅,2007.

[10] Chen YH, Zhao M, Chen X, Zhang Y, Wang H, Huang YY, Wang Z, Zhang ZH, Zhang C, Xu DX. Zinc supplementation during pregnancy protects against lipopolysaccharide-induced fetal growth restriction and demise through its anti-inflammatory effect. 安徽医科大学2012年最具影响力十佳论文. 安徽医科大学,2012.

[11] 陈远华,徐德祥(导师). 妊娠晚期接触细菌脂多糖对胎儿生长发育和骨骼发育的影响. 安徽省优秀硕士学位论文. 安徽省人民政府学位委员会. 2008.

[12] 徐德祥, 王华,宁萑,赵磊,陈远华. 给予母体褪黑素对LPS刺激母鼠血清、羊水、胎肝和胎脑致炎因子和抗炎因子的不同影响. 安徽省自然科学优秀论文一等奖. 安徽省科技厅2009.

[13] 宁萑,王华,赵磊,陈远华,徐德祥. 低剂量细菌脂多糖预处理抑制母体接触细菌脂多糖诱导胎肝和胎脑中肿瘤坏死因子α释放. 安徽省自然科学优秀论文二等奖. 安徽省科技厅,2009.

[14] 赵磊,陈远华,王华,姬艳丽,宁萑,王素芳,张程,吕金伟,段自皞,魏凌珍,徐德祥. 活性氧在细菌脂多糖致畸中的作用. 安徽省自然科学优秀论文三等奖. 安徽省科技厅,2009.

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