1. 简介
博士、校聘副教授。学术兼职：安徽省环境诱变剂学会理事兼秘书、安徽省预防医学会卫生毒理专业委员会委员兼秘书。科学研究：主持国家自然科学基金面上项目、青年科学基金、安徽省自然科学基金面上项目、安徽省教育厅高校自然科学研究重点项目、安徽省高等学校省级优秀青年人才基金项目和安徽医科大学校级科学研究基金课题各1项，参与省部级以上课题多项；以第一作者（含共同第一作者）发表SCI论文14篇。获安徽省优秀硕士学位论文（2009年）、中华预防医学科技奖三等奖（2009年）和中华医学科技奖三等奖（2008年，2014年，2020年）、2011-2012学年校优秀班主任。
2. 教育经历
2016/09-2019/06，安徽医科大学，儿少卫生与妇幼保健学专业，博士研究生
2005/09-2008/06，安徽医科大学，卫生毒理学专业，硕士研究生
1998/09-2003/06，安徽医科大学，预防医学专业，本科生
3. 主持科研项目
[1] 国家自然科学基金面上项目，82173565，内质网应激降低α-酮戊二酸在孕期砷暴露致子代肝脏脂代谢重编程改变中的作用，55万元，在研，主持人。
[2] 安徽省自然科学基金面上项目，2008085MH280，内质网应激感受器IRE1在细菌脂多糖干扰孕期母体胆汁酸代谢中的作用，12万元，在研，主持人。
[3] 国家自然科学基金青年科学基金项目，81001480，内质网应激在利福平致肝细胞脂质代谢紊乱中的作用，20万元，已结题，主持人。
4.代表性SCI论文（*通讯作者）
[1]Bingdong Song #, Cheng Zhang #, Weirong Hu, Chunyu Guo, Zhengmei Xia , Wanxia Hu, Mingqiang Qin , Weiying Jiang, Jinwei Lv, Dexiang Xu, Shichen Zhang* , Jun Fang*, Nano-designed carbon monoxide donor SMA/CORM2 exhibits protective effect against acetaminophen induced liver injury through macrophage reprograming and promoting liver regeneration, J Control Release, 2021, 331: 350-363.
[2] Cheng Zhang#, Yu Gan, Jin-Wei Lv, Ming-Qiang Qin, Wei-Rong Hu , Zhi-Bing Liu, Li Ma, Bing-Dong Song, Jian Li, Wei-Ying Jiang, Jian-Qing Wang, Hua Wang, De-Xiang Xu*, The protective effect of obeticholic acid on lipopolysaccharide-induced disorder of maternal bile acid metabolism in pregnant mice, Int Immunopharmacol, 2020, 83: 106442.
[3] Qian-Qian Chen#, Cheng Zhang#, Ming-Qiang Qin, Jian Li, Hua Wang, De-Xiang Xu*, Jian-Qing Wang*, Inositol-requiring enzyme 1 alpha endoribonuclease specific inhibitor stf-083010 alleviates carbon tetrachloride induced liver injury and liver fibrosis in mice, Front Pharmacol, 2018; 9: 1344.
[4] Da-Gang Zhang#, Cheng Zhang#, Jun-XianWang, Bi-Wei Wang, Hua Wang, Zhi-Hui Zhang, Yuan-Hua Chen, Yan Lu, Li Tao, Jian-Qing Wang, Xi Chen*, De-Xiang Xu*, Obeticholic acid protects against carbon tetrachloride-induced acute liver injury and inflammation, Toxicol Appl Pharmacol, 2017, 314: 39-47.
[5] Jun-Xian Wang#, Cheng Zhang#, Lin Fu, Da-Gang Zhang, Bi-Wei Wang, Zhi-Hui Zhang, Yuan-Hua Chen, Yan Lu, Xi Chen*, De-Xiang Xu*, Protective effect of rosiglitazone against acetaminophen-induced acute liver injury is associated with down-regulation of hepatic NADPH oxidases, Toxicol Lett, 2017, 265: 38-46.
[6] Jia-Hui Huang#, Cheng Zhang#, Da-Gang Zhang, Lu Li, Xi Chen*, De-Xiang Xu*, Rifampicin-Induced Hepatic Lipid Accumulation: Association with Up-Regulation of Peroxisome Proliferator-Activated Receptor γ in Mouse Liver, PLoS One, 2016, 11(11): e0165787.
[7] Ye-Fa Zhang#, Wei He#, Cheng Zhang#, Xiao-Jing Liu, Yan Lu, Hua Wang, Zhi-Hui Zhang, Xi Chen*, De-Xiang Xu*, Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice, Toxicol Lett, 2014, 225(3): 445-453.
[8] Jian-Qing Wang#, Xi Chen#, Cheng Zhang#, Li Tao, Zhi-Hui Zhang, Xiao-Qian Liu, Yuan-Bao Xu, Hua Wang, Jun Li*, De-Xiang Xu*, Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice, Toxicol Appl Pharmacol, 2013, 266(2):307-316.
[9] Cheng Zhang#, Xi Chen#, Ren-Min Zhu#, Ying Zhang, Tao Yu, Hua Wang, Hui Zhao, Mei Zhao, Yan-Li Ji, Yuan-Hua Chen, Xiu-Hong Meng, Wei Wei*, De-Xiang Xu*, Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice, Toxicol Lett, 2012, 212(3): 229-240.
[10] Xi Chen#, Cheng Zhang#, Mei Zhao, Chang-E Shi#, Ren-Min Zhu, Hua Wang, Hui Zhao, Wei Wei, Jia-Bin Li, De-Xiang Xu*, Melatonin alleviates lipopolysaccharide-induced hepatic SREBP-1c activation and lipid accumulation in mice, J Pineal Res, 2011, 51(4): 416-425.
[11] Xi Chen#, Cheng Zhang#, Hua Wang, Juan Xu, Zi-Hao Duan, Ying Zhang, Tao Yu, Wei Wei, De-Xiang Xu*, Jian-Ming Xu*, Altered integrity and decreased expression of hepatocyte tight junctions in rifampicin-induced cholestasis in mice, Toxicol Appl Pharmacol, 2009, 240 (1): 26-36.
[12] Xiang-Yun Li#, Cheng Zhang#, Su-Fang Wang, Yan-Li Ji, Hua Wang, Lei Zhao, De-Xiang Xu*, Maternally-administered lipopolysaccharide (LPS) upregulates the expression of heme oxygenase-1 in fetal liver: the role of reactive oxygen species, Toxicol Lett, 2008, 176 (3): 169-177.
[13] Xiang-Yun Li#, Cheng Zhang#, HuaWang, Yan-Li Ji, Su-FangWang, Lei Zhao, Xi Chen, De-Xiang Xu*, Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced downregulation of CYP3A in fetal liver: its repression by a low dose LPS pretreatment, Toxicol Lett, 2008, 179 (2): 71-77.
[14] Cheng Zhang, Xiang-Yun Li, Lei Zhao, Hua Wang, De-Xiang Xu*, Lipopolysaccharide (LPS) up-regulates the expression of haem oxygenase-1 in mouse placenta, Placenta, 2007, 28 (8-9): 951-957.